Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin
Silk fibroin, known for its biocompatibility and biodegradability, holds significant promise for biomedical applications, particularly in drug delivery systems. The precise fabrication of silk fibroin particles, specifically those ranging from tens of nanometres to hundreds of microns, is critical f...
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MDPI AG
2025-01-01
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| author | Zhengjian Wang Xichun Luo Jining Sun Wenkun Xie Yinchuan Piao Yonghang Jiang Xiuyuan Chen |
| author_facet | Zhengjian Wang Xichun Luo Jining Sun Wenkun Xie Yinchuan Piao Yonghang Jiang Xiuyuan Chen |
| author_sort | Zhengjian Wang |
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| description | Silk fibroin, known for its biocompatibility and biodegradability, holds significant promise for biomedical applications, particularly in drug delivery systems. The precise fabrication of silk fibroin particles, specifically those ranging from tens of nanometres to hundreds of microns, is critical for these uses. This study introduces elliptical vibration micro-turning as a method for producing silk fibroin particles in the form of cutting chips to serve as carriers for drug delivery systems. A hybrid finite element and smoothed particle hydrodynamics (FE-SPH) model was used to investigate how vibration parameters, such as frequency and amplitude, influence chip formation and morphology. This research is essential for determining the size and shape of silk fibroin particles, which are crucial for their effectiveness in drug delivery systems. The results demonstrate the superior capability of elliptical vibration micro-turning for producing shorter, spiral-shaped chips in the size range of tens of microns, in contrast to the long, continuous chips with zig-zag folds and segmented edges generated by conventional micro-turning. The unique zig-zag shapes result from the interplay between the high flexibility and hierarchical structure of silk fibroin and the controlled cutting environment provided by the diamond tool. Additionally, higher vibration frequencies and lower vertical amplitudes promote chip curling, facilitate breakage, and improve chip control, while reducing cutting forces. Experimental trials further validate the accuracy of the hybrid model. This study represents a significant advancement in the processing of silk fibroin film, offering a complementary approach to fabricating short, spiral-shaped silk fibroin particles with a high surface-area-to-volume ratio compared to traditional spheroids, which holds great potential for enhancing drug-loading efficiency in high-precision drug delivery systems. |
| format | Article |
| id | doaj-art-ade2dc668908488b95a642abcbc7585e |
| institution | Kabale University |
| issn | 2072-666X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj-art-ade2dc668908488b95a642abcbc7585e2025-01-24T13:42:13ZengMDPI AGMicromachines2072-666X2025-01-0116111010.3390/mi16010110Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk FibroinZhengjian Wang0Xichun Luo1Jining Sun2Wenkun Xie3Yinchuan Piao4Yonghang Jiang5Xiuyuan Chen6Centre for Precision Manufacturing, DMEM, University of Strathclyde, Glasgow G1 1XJ, UKCentre for Precision Manufacturing, DMEM, University of Strathclyde, Glasgow G1 1XJ, UKSchool of Mechanical Engineering, Dalian University of Technology, Dalian 116023, ChinaCentre for Precision Manufacturing, DMEM, University of Strathclyde, Glasgow G1 1XJ, UKCentre for Precision Manufacturing, DMEM, University of Strathclyde, Glasgow G1 1XJ, UKCentre for Precision Manufacturing, DMEM, University of Strathclyde, Glasgow G1 1XJ, UKCentre for Precision Manufacturing, DMEM, University of Strathclyde, Glasgow G1 1XJ, UKSilk fibroin, known for its biocompatibility and biodegradability, holds significant promise for biomedical applications, particularly in drug delivery systems. The precise fabrication of silk fibroin particles, specifically those ranging from tens of nanometres to hundreds of microns, is critical for these uses. This study introduces elliptical vibration micro-turning as a method for producing silk fibroin particles in the form of cutting chips to serve as carriers for drug delivery systems. A hybrid finite element and smoothed particle hydrodynamics (FE-SPH) model was used to investigate how vibration parameters, such as frequency and amplitude, influence chip formation and morphology. This research is essential for determining the size and shape of silk fibroin particles, which are crucial for their effectiveness in drug delivery systems. The results demonstrate the superior capability of elliptical vibration micro-turning for producing shorter, spiral-shaped chips in the size range of tens of microns, in contrast to the long, continuous chips with zig-zag folds and segmented edges generated by conventional micro-turning. The unique zig-zag shapes result from the interplay between the high flexibility and hierarchical structure of silk fibroin and the controlled cutting environment provided by the diamond tool. Additionally, higher vibration frequencies and lower vertical amplitudes promote chip curling, facilitate breakage, and improve chip control, while reducing cutting forces. Experimental trials further validate the accuracy of the hybrid model. This study represents a significant advancement in the processing of silk fibroin film, offering a complementary approach to fabricating short, spiral-shaped silk fibroin particles with a high surface-area-to-volume ratio compared to traditional spheroids, which holds great potential for enhancing drug-loading efficiency in high-precision drug delivery systems.https://www.mdpi.com/2072-666X/16/1/110elliptical vibration micro-turningsmoothed particle hydrodynamicschip morphologysilk fibroincutting chipssilk fibroin particles |
| spellingShingle | Zhengjian Wang Xichun Luo Jining Sun Wenkun Xie Yinchuan Piao Yonghang Jiang Xiuyuan Chen Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin Micromachines elliptical vibration micro-turning smoothed particle hydrodynamics chip morphology silk fibroin cutting chips silk fibroin particles |
| title | Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin |
| title_full | Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin |
| title_fullStr | Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin |
| title_full_unstemmed | Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin |
| title_short | Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin |
| title_sort | investigation of chip morphology in elliptical vibration micro turning of silk fibroin |
| topic | elliptical vibration micro-turning smoothed particle hydrodynamics chip morphology silk fibroin cutting chips silk fibroin particles |
| url | https://www.mdpi.com/2072-666X/16/1/110 |
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