Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis
Abstract Background Despite the well-documented immune dysregulation in both psoriasis and Sjögren’s syndrome (SS), the specific link between these two autoimmune diseases has not been extensively explored. The present study aims to investigate the impact of psoriasis on the risk of SS. Methods A re...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12916-025-03856-y |
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| author | Zijian Kang Yu Du Ran Cui Qian Wang Miao Chen Yu-Hsun Wang James Cheng‐Chung Wei Sheng-Ming Dai |
| author_facet | Zijian Kang Yu Du Ran Cui Qian Wang Miao Chen Yu-Hsun Wang James Cheng‐Chung Wei Sheng-Ming Dai |
| author_sort | Zijian Kang |
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| description | Abstract Background Despite the well-documented immune dysregulation in both psoriasis and Sjögren’s syndrome (SS), the specific link between these two autoimmune diseases has not been extensively explored. The present study aims to investigate the impact of psoriasis on the risk of SS. Methods A retrospective cohort study using TriNetX data compared SS development in patients with psoriasis and controls using propensity score matching, Kaplan–Meier curves, and Cox models. Transcriptome data were analyzed to identify shared differentially expressed genes and pathways between the two diseases. Results A total of 293,905 patients with psoriasis and an equal number of individuals without psoriasis were included. After propensity score matching, the baseline characteristics of both groups were balanced. During the follow-up period, 3339 patients with psoriasis and 1937 individuals without psoriasis developed SS. The Kaplan–Meier curves indicated a significantly higher risk of developing SS in the psoriasis group compared to the non-psoriasis group. Upon adjustment for multiple confounding factors, the risk of developing SS in the psoriasis group was 50% higher in the psoriasis group than the non-psoriasis group (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.42–1.58). Subgroup analyses confirmed the elevated risk of SS associated with psoriasis. Patients with psoriatic arthritis (PsA) and those treated with biological agents had an even higher risk of developing SS. Transcriptomic analysis revealed potential shared pathogenesis of psoriasis and SS involving cellular proliferation, immune cell recruitment, cytokine secretion, and the interferon response to viral infections. Conclusions Psoriasis might increase the risk of developing SS, which is augmented by PsA. The overlapping immunological mechanisms may underlie the co-occurrence of psoriasis and SS. |
| format | Article |
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| institution | Kabale University |
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| language | English |
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| series | BMC Medicine |
| spelling | doaj-art-add700dcaef340aa8beec8d6d364d5f42025-01-26T12:37:17ZengBMCBMC Medicine1741-70152025-01-0123111110.1186/s12916-025-03856-yPsoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysisZijian Kang0Yu Du1Ran Cui2Qian Wang3Miao Chen4Yu-Hsun Wang5James Cheng‐Chung Wei6Sheng-Ming Dai7Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Medical Research, Chung Shan Medical University HospitalShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi HospitalDepartment of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Background Despite the well-documented immune dysregulation in both psoriasis and Sjögren’s syndrome (SS), the specific link between these two autoimmune diseases has not been extensively explored. The present study aims to investigate the impact of psoriasis on the risk of SS. Methods A retrospective cohort study using TriNetX data compared SS development in patients with psoriasis and controls using propensity score matching, Kaplan–Meier curves, and Cox models. Transcriptome data were analyzed to identify shared differentially expressed genes and pathways between the two diseases. Results A total of 293,905 patients with psoriasis and an equal number of individuals without psoriasis were included. After propensity score matching, the baseline characteristics of both groups were balanced. During the follow-up period, 3339 patients with psoriasis and 1937 individuals without psoriasis developed SS. The Kaplan–Meier curves indicated a significantly higher risk of developing SS in the psoriasis group compared to the non-psoriasis group. Upon adjustment for multiple confounding factors, the risk of developing SS in the psoriasis group was 50% higher in the psoriasis group than the non-psoriasis group (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.42–1.58). Subgroup analyses confirmed the elevated risk of SS associated with psoriasis. Patients with psoriatic arthritis (PsA) and those treated with biological agents had an even higher risk of developing SS. Transcriptomic analysis revealed potential shared pathogenesis of psoriasis and SS involving cellular proliferation, immune cell recruitment, cytokine secretion, and the interferon response to viral infections. Conclusions Psoriasis might increase the risk of developing SS, which is augmented by PsA. The overlapping immunological mechanisms may underlie the co-occurrence of psoriasis and SS.https://doi.org/10.1186/s12916-025-03856-yPsoriasisSjögren’s syndromePropensity score matchingRisk factors |
| spellingShingle | Zijian Kang Yu Du Ran Cui Qian Wang Miao Chen Yu-Hsun Wang James Cheng‐Chung Wei Sheng-Ming Dai Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis BMC Medicine Psoriasis Sjögren’s syndrome Propensity score matching Risk factors |
| title | Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis |
| title_full | Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis |
| title_fullStr | Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis |
| title_full_unstemmed | Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis |
| title_short | Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis |
| title_sort | psoriasis increases the risk of sjogren s syndrome evidence from a propensity score matched cohort study and transcriptomic analysis |
| topic | Psoriasis Sjögren’s syndrome Propensity score matching Risk factors |
| url | https://doi.org/10.1186/s12916-025-03856-y |
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