THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis

THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis

Summary: Cancer-associated fibroblasts (CAFs) display significant functional and molecular heterogeneity within the tumor microenvironment, playing diverse roles in cancer progression. Employing single-cell RNA sequencing data of colorectal cancer (CRC), we identified a subset of matrix CAFs (mCAFs)...

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Main Authors: Zaoqu Liu, Yuhao Ba, Dan Shan, Xing Zhou, Anning Zuo, Yuyuan Zhang, Hui Xu, Shutong Liu, Benyu Liu, Yanan Zhao, Siyuan Weng, Ruizhi Wang, Jinhai Deng, Peng Luo, Quan Cheng, Xin Hu, Shuaixi Yang, Fubing Wang, Xinwei Han
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003262
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