Lower circulating mitochondrial DNA and increased mitokines suggest significant mitochondrial dysfunction in systemic lupus erythematosus with renal involvement

Lower circulating mitochondrial DNA and increased mitokines suggest significant mitochondrial dysfunction in systemic lupus erythematosus with renal involvement

Background SLE is associated with significant morbidity, especially in the case of renal involvement. Mitochondrial dysfunction plays a significant role in SLE and may be assessed by measuring mitochondrial DNA (mtDNA) and cytokines reflecting mitochondrial stress (mitokines). Circulating mtDNA is a...

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Bibliographic Details
Main Authors: Camillo Ribi, Kristina Sundquist, Matthieu Halfon, Manuel Pascual, Ashfaque A Memon, Anna Hedelius
Format: Article
Language:English
Published: BMJ Publishing Group 2025-02-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/12/1/e001368.full
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