Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism
This study investigates the potential of ionic liquids (ILs) as sustainable solvents in ultrasonic-assisted extraction (UAE) to efficiently recover luteolin from peanut shells. Among the range of ILs tested, 1-butyl-3-methylimidazolium tetrafluoroborate stood out as the most effective solvent, achie...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000070 |
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| author | Liwei Niu Siwen Zhang Xiaoyu Si Yuhan Fang Shuang Wang Lulu Li Zunlai Sheng |
| author_facet | Liwei Niu Siwen Zhang Xiaoyu Si Yuhan Fang Shuang Wang Lulu Li Zunlai Sheng |
| author_sort | Liwei Niu |
| collection | DOAJ |
| description | This study investigates the potential of ionic liquids (ILs) as sustainable solvents in ultrasonic-assisted extraction (UAE) to efficiently recover luteolin from peanut shells. Among the range of ILs tested, 1-butyl-3-methylimidazolium tetrafluoroborate stood out as the most effective solvent, achieving the highest extraction yield. Single-factor experiments were conducted to analyze the effects of ultrasonic power, extraction time, extraction temperature, IL concentration, and solid-to-liquid ratio on extraction efficiency. Further optimization of the extraction conditions was performed using response surface methodology and neural network analysis, resulting in a significantly enhanced luteolin yield of 3.71 ± 0.06 mg/g. Interaction energy analyses were conducted to elucidate the interactions between ILs and luteolin, confirming the experimental findings and highlighting the strongest interaction energy between 1-butyl-3-methylimidazolium tetrafluoroborate and luteolin. A kinetic model for luteolin extraction was developed, demonstrating that the extraction process follows a second-order rate model, where the extraction rate is directly proportional to the square of the concentration difference between luteolin and the solvent. The outcomes of this research present an efficient protocol for luteolin extraction and provide novel insights into the application of UAE in extracting natural products. |
| format | Article |
| id | doaj-art-adabffd3849e4e22a11232ce87e00368 |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-adabffd3849e4e22a11232ce87e003682025-02-01T04:11:37ZengElsevierUltrasonics Sonochemistry1350-41772025-02-01113107228Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanismLiwei Niu0Siwen Zhang1Xiaoyu Si2Yuhan Fang3Shuang Wang4Lulu Li5Zunlai Sheng6College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR China; Corresponding author at: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.This study investigates the potential of ionic liquids (ILs) as sustainable solvents in ultrasonic-assisted extraction (UAE) to efficiently recover luteolin from peanut shells. Among the range of ILs tested, 1-butyl-3-methylimidazolium tetrafluoroborate stood out as the most effective solvent, achieving the highest extraction yield. Single-factor experiments were conducted to analyze the effects of ultrasonic power, extraction time, extraction temperature, IL concentration, and solid-to-liquid ratio on extraction efficiency. Further optimization of the extraction conditions was performed using response surface methodology and neural network analysis, resulting in a significantly enhanced luteolin yield of 3.71 ± 0.06 mg/g. Interaction energy analyses were conducted to elucidate the interactions between ILs and luteolin, confirming the experimental findings and highlighting the strongest interaction energy between 1-butyl-3-methylimidazolium tetrafluoroborate and luteolin. A kinetic model for luteolin extraction was developed, demonstrating that the extraction process follows a second-order rate model, where the extraction rate is directly proportional to the square of the concentration difference between luteolin and the solvent. The outcomes of this research present an efficient protocol for luteolin extraction and provide novel insights into the application of UAE in extracting natural products.http://www.sciencedirect.com/science/article/pii/S1350417725000070Peanut shellsLuteolinIonic liquidsUltrasound-assisted extractionInteraction energyExtraction kinetics |
| spellingShingle | Liwei Niu Siwen Zhang Xiaoyu Si Yuhan Fang Shuang Wang Lulu Li Zunlai Sheng Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism Ultrasonics Sonochemistry Peanut shells Luteolin Ionic liquids Ultrasound-assisted extraction Interaction energy Extraction kinetics |
| title | Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism |
| title_full | Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism |
| title_fullStr | Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism |
| title_full_unstemmed | Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism |
| title_short | Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism |
| title_sort | ultrasonic assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism |
| topic | Peanut shells Luteolin Ionic liquids Ultrasound-assisted extraction Interaction energy Extraction kinetics |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000070 |
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