TNF Superfamily: A Growing Saga of Kidney Injury Modulators
Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy re...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/182958 |
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| author | Maria D. Sanchez-Niño Alberto Benito-Martin Sara Gonçalves Ana B. Sanz Alvaro C. Ucero Maria C. Izquierdo Adrian M. Ramos Sergio Berzal Rafael Selgas Marta Ruiz-Ortega Jesus Egido Alberto Ortiz |
| author_facet | Maria D. Sanchez-Niño Alberto Benito-Martin Sara Gonçalves Ana B. Sanz Alvaro C. Ucero Maria C. Izquierdo Adrian M. Ramos Sergio Berzal Rafael Selgas Marta Ruiz-Ortega Jesus Egido Alberto Ortiz |
| author_sort | Maria D. Sanchez-Niño |
| collection | DOAJ |
| description | Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy. TRAIL activates NF-kappaB in tubular cells and promotes apoptosis in tubular cells and podocytes, especially in a high-glucose environment. By contrast, osteoprotegerin plays a protective role against TRAIL-induced apoptosis. Another family member, TNF-like weak inducer of apoptosis (TWEAK induces inflammation and tubular cell death or proliferation, depending on the microenvironment. While TNF only activates canonical NF-kappaB signaling, TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells, regulating different inflammatory responses. TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes. In vivo TWEAK promotes postnephrectomy compensatory renal cell proliferation in a noninflammatory milieu. However, in the inflammatory milieu of acute kidney injury, TWEAK promotes tubular cell death and inflammation. Therapeutic targeting of TNF superfamily cytokines, including multipronged approaches targeting several cytokines should be further explored. |
| format | Article |
| id | doaj-art-ad9801b9bc514826b72838f5e4f46c07 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ad9801b9bc514826b72838f5e4f46c072025-02-03T06:42:10ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/182958182958TNF Superfamily: A Growing Saga of Kidney Injury ModulatorsMaria D. Sanchez-Niño0Alberto Benito-Martin1Sara Gonçalves2Ana B. Sanz3Alvaro C. Ucero4Maria C. Izquierdo5Adrian M. Ramos6Sergio Berzal7Rafael Selgas8Marta Ruiz-Ortega9Jesus Egido10Alberto Ortiz11IIS- Fundación Jiménez Díaz, 28040 Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainNefrologia e Transplantação Renal, Hospital de Santa Maria, CHLN, EPE, 1600 Lisbon, PortugalServicio de Nefrologia, Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz, RedinREN, Instituto de Salud Carlos III, Fondos FEDER, 28046 Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainServicio de Nefrologia, Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz, RedinREN, Instituto de Salud Carlos III, Fondos FEDER, 28046 Madrid, SpainUniversidad Autónoma de Madrid, Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainIIS- Fundación Jiménez Díaz, 28040 Madrid, SpainMembers of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy. TRAIL activates NF-kappaB in tubular cells and promotes apoptosis in tubular cells and podocytes, especially in a high-glucose environment. By contrast, osteoprotegerin plays a protective role against TRAIL-induced apoptosis. Another family member, TNF-like weak inducer of apoptosis (TWEAK induces inflammation and tubular cell death or proliferation, depending on the microenvironment. While TNF only activates canonical NF-kappaB signaling, TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells, regulating different inflammatory responses. TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes. In vivo TWEAK promotes postnephrectomy compensatory renal cell proliferation in a noninflammatory milieu. However, in the inflammatory milieu of acute kidney injury, TWEAK promotes tubular cell death and inflammation. Therapeutic targeting of TNF superfamily cytokines, including multipronged approaches targeting several cytokines should be further explored.http://dx.doi.org/10.1155/2010/182958 |
| spellingShingle | Maria D. Sanchez-Niño Alberto Benito-Martin Sara Gonçalves Ana B. Sanz Alvaro C. Ucero Maria C. Izquierdo Adrian M. Ramos Sergio Berzal Rafael Selgas Marta Ruiz-Ortega Jesus Egido Alberto Ortiz TNF Superfamily: A Growing Saga of Kidney Injury Modulators Mediators of Inflammation |
| title | TNF Superfamily: A Growing Saga of Kidney Injury Modulators |
| title_full | TNF Superfamily: A Growing Saga of Kidney Injury Modulators |
| title_fullStr | TNF Superfamily: A Growing Saga of Kidney Injury Modulators |
| title_full_unstemmed | TNF Superfamily: A Growing Saga of Kidney Injury Modulators |
| title_short | TNF Superfamily: A Growing Saga of Kidney Injury Modulators |
| title_sort | tnf superfamily a growing saga of kidney injury modulators |
| url | http://dx.doi.org/10.1155/2010/182958 |
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