Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways.

Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways.

<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in >90% of pancreatic cancer...

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Main Authors: Zhiwei Wang, Sanjeev Banerjee, Aamir Ahmad, Yiwei Li, Asfar S Azmi, Jason R Gunn, Dejuan Kong, Bin Bao, Shadan Ali, Jiankun Gao, Ramzi M Mohammad, Lucio Miele, Murray Korc, Fazlul H Sarkar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020537&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020537&type=printable

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