Ca2+-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range

Ca2+-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range

Abstract Ca2+-ATPases in the plasma membrane extrude Ca2+ ions from the cytosol to the extracellular space thereby terminating Ca2+-signals and controlling Ca2+-homeostasis in any type of cell. Recently, these Ca2+-pumps have been identified as protein complexes of the transporting subunits PMCAs1-4...

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Main Authors: Cristina E. Constantin, Barbara Schmidt, Yvonne Schwarz, Harumi Harada, Astrid Kollewe, Catrin S. Müller, Sebastian Henrich, Botond Gaal, Akos Kulik, Dieter Bruns, Uwe Schulte, Heiko Rieger, Bernd Fakler
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62735-5
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