Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors

Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors

A major intracellular messenger implicated in synaptic plasticity and cognitive functions both in health and disease is cyclic GMP (cGMP). Utilizing a photoactivatable guanylyl cyclase (BlgC) actuator to increase cGMP in dentate granule neurons of the hippocampus by light, we studied the effects of...

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Bibliographic Details
Main Authors: Jelena Borovac, Jayant Rai, Megan Valencia, Hang Li, John Georgiou, Graham L. Collingridge, Keizo Takao, Kenichi Okamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cGMP
optogenetics
electrophysiology
long-term potentiation
synaptic plasticity
memory
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1479360/full
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