Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs
Abstract Non-invasive physical plasma (NIPP) has been used effectively for wound healing in human medicine for over two decades. The advantages are that NIPP has few side effects, is painless and gentle on the tissue. The therapeutic effect is mediated by reactive oxygen species (ROS). Based on the...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-86376-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585732443602944 |
|---|---|
| author | Jürgen Eichler Björn Rulik Alexander Abazid Matthias B. Stope |
| author_facet | Jürgen Eichler Björn Rulik Alexander Abazid Matthias B. Stope |
| author_sort | Jürgen Eichler |
| collection | DOAJ |
| description | Abstract Non-invasive physical plasma (NIPP) has been used effectively for wound healing in human medicine for over two decades. The advantages are that NIPP has few side effects, is painless and gentle on the tissue. The therapeutic effect is mediated by reactive oxygen species (ROS). Based on the biomedical effects known to date, it can be assumed that NIPP can also be used for wound treatment in non-human mammals. In this prospective, non-randomized monocentric clinical trial, 43 European hedgehogs with cut and bite wounds were treated with conventional wound management (CWM: 21 patients) and compared with 22 patients with CWM plus NIPP treatment (CWM + NIPP). Under NIPP treatment, patients showed no signs of pain, stress or discomfort, even after several applications. In 76% of CWM + NIPP patients, three or four NIPP applications were sufficient. In patients in the CWM + NIPP group, wound treatment was completed statistically significantly 6 d earlier (CWM: 19.0 d versus CWM + NIPP: 13.2 d; p = 0.0008). This wildlife clinical trial demonstrates that NIPP can be used to improve wound healing in wild European hedgehogs. It is conceivable that NIPP therapy could also lead to positive effects in other injured wild animals, domestic animals or livestock. |
| format | Article |
| id | doaj-art-ad2b1e5ea94346d8bd849dd4bf7cd62f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ad2b1e5ea94346d8bd849dd4bf7cd62f2025-01-26T12:34:34ZengNature PortfolioScientific Reports2045-23222025-01-0115111410.1038/s41598-025-86376-2Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogsJürgen Eichler0Björn Rulik1Alexander Abazid2Matthias B. Stope3Tierarztpraxis im Frauenviertel, Small Animal Veterinary PracticeZoological Research Museum Alexander Koenig, Leibniz Institute for the Analysis of Biodiversity ChangeDepartment of General, Visceral and Thorax Surgery, Bundeswehr Hospital BerlinPhysical Plasma Medicine Laboratories, Department of Gynecology and Gynecological Oncology, University Hospital BonnAbstract Non-invasive physical plasma (NIPP) has been used effectively for wound healing in human medicine for over two decades. The advantages are that NIPP has few side effects, is painless and gentle on the tissue. The therapeutic effect is mediated by reactive oxygen species (ROS). Based on the biomedical effects known to date, it can be assumed that NIPP can also be used for wound treatment in non-human mammals. In this prospective, non-randomized monocentric clinical trial, 43 European hedgehogs with cut and bite wounds were treated with conventional wound management (CWM: 21 patients) and compared with 22 patients with CWM plus NIPP treatment (CWM + NIPP). Under NIPP treatment, patients showed no signs of pain, stress or discomfort, even after several applications. In 76% of CWM + NIPP patients, three or four NIPP applications were sufficient. In patients in the CWM + NIPP group, wound treatment was completed statistically significantly 6 d earlier (CWM: 19.0 d versus CWM + NIPP: 13.2 d; p = 0.0008). This wildlife clinical trial demonstrates that NIPP can be used to improve wound healing in wild European hedgehogs. It is conceivable that NIPP therapy could also lead to positive effects in other injured wild animals, domestic animals or livestock.https://doi.org/10.1038/s41598-025-86376-2Cold plasmaCold atmospheric plasmaTissue tolerable plasmaPlasma medicinePhysical plasma medicineWound healing |
| spellingShingle | Jürgen Eichler Björn Rulik Alexander Abazid Matthias B. Stope Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs Scientific Reports Cold plasma Cold atmospheric plasma Tissue tolerable plasma Plasma medicine Physical plasma medicine Wound healing |
| title | Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs |
| title_full | Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs |
| title_fullStr | Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs |
| title_full_unstemmed | Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs |
| title_short | Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs |
| title_sort | non invasive physical plasma improves conventional wound management of cut and bite wounds in wild european hedgehogs |
| topic | Cold plasma Cold atmospheric plasma Tissue tolerable plasma Plasma medicine Physical plasma medicine Wound healing |
| url | https://doi.org/10.1038/s41598-025-86376-2 |
| work_keys_str_mv | AT jurgeneichler noninvasivephysicalplasmaimprovesconventionalwoundmanagementofcutandbitewoundsinwildeuropeanhedgehogs AT bjornrulik noninvasivephysicalplasmaimprovesconventionalwoundmanagementofcutandbitewoundsinwildeuropeanhedgehogs AT alexanderabazid noninvasivephysicalplasmaimprovesconventionalwoundmanagementofcutandbitewoundsinwildeuropeanhedgehogs AT matthiasbstope noninvasivephysicalplasmaimprovesconventionalwoundmanagementofcutandbitewoundsinwildeuropeanhedgehogs |