Guanine quadruplexes mediate mitochondrial RNA polymerase pausing

Guanine quadruplexes mediate mitochondrial RNA polymerase pausing

Abstract Background The information content within nucleic acids extends beyond the primary sequence to include secondary structures with functional roles in transcription regulation. Guanine-rich sequences form structures called guanine quadruplexes that result from non-canonical base pairing betwe...

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Bibliographic Details
Main Authors: Ryan J. Snyder, Uma Shankar, Don Delker, Winny Soerianto, Joshua T. Burdick, Vivian G. Cheung, Jason A. Watts
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
RNA polymerase pausing
Transcription
Guanine quadruplex
Mitochondria
Proximal tubule
Online Access:https://doi.org/10.1186/s12915-025-02229-4
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https://doi.org/10.1186/s12915-025-02229-4

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