Validation of an LC–HRMS Method for Quantifying Indoxyl Sulfate and <i>p</i>-Cresyl Sulfate in Human Serum

Validation of an LC–HRMS Method for Quantifying Indoxyl Sulfate and <i>p</i>-Cresyl Sulfate in Human Serum

Accurate quantification of indoxyl sulfate (IndS) and <i>p</i>-cresyl sulfate (pCS) is essential for understanding their role in chronic kidney disease (CKD) progression and for developing strategies to mitigate their harmful effects, including cardiovascular morbidity and renal fibrosis...

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Main Authors: María Rodríguez-García, Irene Martínez, Irene Aliart, Jaime I. Sainz de Medrano, Nayra Rico, Víctor Joaquín Escudero-Saiz, Francisco Maduell, Manuel Morales-Ruiz, Gregori Casals
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
chronic kidney disease
uremic toxins
high-resolution mass spectrometry
micro-liquid chromatography
hemodiafiltration
metabolomics
Online Access:https://www.mdpi.com/1420-3049/30/4/782
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