Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection
We report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking. Male Wistar rats drank ad libitum regular cola (C, n=12) or tap water (W, n=12). Measures. Body weight, nutritional data, plasma glucose, cholesterol fractio...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5613056 |
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| author | Matilde Otero-Losada Hernán Gómez Llambí Graciela Ottaviano Gabriel Cao Angélica Müller Francisco Azzato Giuseppe Ambrosio José Milei |
| author_facet | Matilde Otero-Losada Hernán Gómez Llambí Graciela Ottaviano Gabriel Cao Angélica Müller Francisco Azzato Giuseppe Ambrosio José Milei |
| author_sort | Matilde Otero-Losada |
| collection | DOAJ |
| description | We report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking. Male Wistar rats drank ad libitum regular cola (C, n=12) or tap water (W, n=12). Measures. Body weight, nutritional data, plasma glucose, cholesterol fractions, TG, urea, creatinine, coenzyme Q10, SBP, and echocardiograms (0 mo and 6 mo). At 6 months euthanasia was performed. Kidneys were processed for histopathology and immunohistochemistry (semiquantitative). Compared with W, C rats showed (I) overweight (+8%, p<0.05), hyperglycemia (+11%, p<0.05), hypertriglyceridemia (2-fold, p<0.001), higher AIP (2-fold, p<0.01), and lower Q10 level (−55%, p<0.05); (II) increased LV diastolic diameter (+9%, p<0.05) and volume (systolic +24%, p<0.05), posterior wall thinning (−8%, p<0.05), and larger cardiac output (+24%, p<0.05); (III) glomerulosclerosis (+21%, p<0.05), histopathology (+13%, p<0.05), higher tubular expression of IL-6 (7-fold, p<0.001), and TNFα (4-fold, p<0.001). (IV) Correlations were found for LV dimensions with IL-6 (74%, p<0.001) and TNFα (52%, p<0.001) and fully abolished after TG and Q10 control. Chronic cola drinking induced cardiac remodeling associated with increase in proinflammatory cytokines and renal damage. Hypertriglyceridemia and oxidative stress were key factors. Hypertriglyceridemic lipotoxicity in the context of defective antioxidant/anti-inflammatory protection due to low Q10 level might play a key role in cardiorenal disorder induced by chronic cola drinking in rats. |
| format | Article |
| id | doaj-art-acfd9f8050b542d5bbbe7944fade2b63 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-acfd9f8050b542d5bbbe7944fade2b632025-02-03T01:33:01ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/56130565613056Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative ProtectionMatilde Otero-Losada0Hernán Gómez Llambí1Graciela Ottaviano2Gabriel Cao3Angélica Müller4Francisco Azzato5Giuseppe Ambrosio6José Milei7Institute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaInstitute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaInstitute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaInstitute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaInstitute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaInstitute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaUniversity of Perugia School of Medicine, 06132 Perugia, ItalyInstitute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA, UBA, CONICET), 1122 Buenos Aires, ArgentinaWe report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking. Male Wistar rats drank ad libitum regular cola (C, n=12) or tap water (W, n=12). Measures. Body weight, nutritional data, plasma glucose, cholesterol fractions, TG, urea, creatinine, coenzyme Q10, SBP, and echocardiograms (0 mo and 6 mo). At 6 months euthanasia was performed. Kidneys were processed for histopathology and immunohistochemistry (semiquantitative). Compared with W, C rats showed (I) overweight (+8%, p<0.05), hyperglycemia (+11%, p<0.05), hypertriglyceridemia (2-fold, p<0.001), higher AIP (2-fold, p<0.01), and lower Q10 level (−55%, p<0.05); (II) increased LV diastolic diameter (+9%, p<0.05) and volume (systolic +24%, p<0.05), posterior wall thinning (−8%, p<0.05), and larger cardiac output (+24%, p<0.05); (III) glomerulosclerosis (+21%, p<0.05), histopathology (+13%, p<0.05), higher tubular expression of IL-6 (7-fold, p<0.001), and TNFα (4-fold, p<0.001). (IV) Correlations were found for LV dimensions with IL-6 (74%, p<0.001) and TNFα (52%, p<0.001) and fully abolished after TG and Q10 control. Chronic cola drinking induced cardiac remodeling associated with increase in proinflammatory cytokines and renal damage. Hypertriglyceridemia and oxidative stress were key factors. Hypertriglyceridemic lipotoxicity in the context of defective antioxidant/anti-inflammatory protection due to low Q10 level might play a key role in cardiorenal disorder induced by chronic cola drinking in rats.http://dx.doi.org/10.1155/2016/5613056 |
| spellingShingle | Matilde Otero-Losada Hernán Gómez Llambí Graciela Ottaviano Gabriel Cao Angélica Müller Francisco Azzato Giuseppe Ambrosio José Milei Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection Mediators of Inflammation |
| title | Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection |
| title_full | Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection |
| title_fullStr | Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection |
| title_full_unstemmed | Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection |
| title_short | Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection |
| title_sort | cardiorenal involvement in metabolic syndrome induced by cola drinking in rats proinflammatory cytokines and impaired antioxidative protection |
| url | http://dx.doi.org/10.1155/2016/5613056 |
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