Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation

Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation

Dysregulation of immune homeostasis accompanied by regulatory T cell (Treg) dysfunction is a hallmark of various autoimmune and inflammatory diseases. While low-dose interleukin-2 (IL-2) treatment can enhance Treg levels and alleviate disease symptoms, its short half-life necessitates frequent dosin...

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Bibliographic Details
Main Authors: Masahiro Ikeda, Shinpei Yamaguchi, Shigeki Takaoka, Yasuko Sakaguchi, Shunki Yasui
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Journal of Translational Autoimmunity
Subjects:
Regulatory T cell
Interleukin-2
IL-2 receptor
Autoimmune disease
Inflammatory disease
Novel therapeutic
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909025000413
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