Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes
Refractory infections caused by multidrug-resistant bacteria pose a significant threat to public health. Here we report that ibuprofen inhibits conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, blaNDM, blaKPC, tet(X4), and tmexCD1-...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716525000153 |
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| author | Guangfen Zhang Chunli Li Xiaofan Li Yuanyuan Li Yunbing Li Xiangkun Zeng Chen Xu Shuyan Wu Ning Dong |
| author_facet | Guangfen Zhang Chunli Li Xiaofan Li Yuanyuan Li Yunbing Li Xiangkun Zeng Chen Xu Shuyan Wu Ning Dong |
| author_sort | Guangfen Zhang |
| collection | DOAJ |
| description | Refractory infections caused by multidrug-resistant bacteria pose a significant threat to public health. Here we report that ibuprofen inhibits conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, blaNDM, blaKPC, tet(X4), and tmexCD1-toprJ1. Mechanistic studies suggest that ibuprofen reduces ATP production and inhibits conjugation-related genes. The inhibitory effect of ibuprofen on conjugation has significant clinical implications for preventing the spread of multidrug resistance, opening new therapeutic avenues to combat multidrug-resistant bacteria. |
| format | Article |
| id | doaj-art-acdc9a4d70b34a6fbb0a30df1a7f89a2 |
| institution | OA Journals |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-acdc9a4d70b34a6fbb0a30df1a7f89a22025-08-20T02:14:22ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-05-0142101410.1016/j.jgar.2025.01.012Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genesGuangfen Zhang0Chunli Li1Xiaofan Li2Yuanyuan Li3Yunbing Li4Xiangkun Zeng5Chen Xu6Shuyan Wu7Ning Dong8MOE Key Laboratory of Geriatric Diseases & Immunology, Suzhou Key Laboratory of Pathogen Bioscience & Anti-infective Medicine, Department of Medical Microbiology, School of Basic Medical Science, Suzhou Medical College, Soochow University, Suzhou, China; School of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaMOE Key Laboratory of Geriatric Diseases & Immunology, Suzhou Key Laboratory of Pathogen Bioscience & Anti-infective Medicine, Department of Medical Microbiology, School of Basic Medical Science, Suzhou Medical College, Soochow University, Suzhou, China; School of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaSchool of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Medical Microbiology, Experimental Center, Medical College of Soochow University, Suzhou, ChinaDepartment of Medical Microbiology, Experimental Center, Medical College of Soochow University, Suzhou, ChinaMOE Key Laboratory of Geriatric Diseases & Immunology, Suzhou Key Laboratory of Pathogen Bioscience & Anti-infective Medicine, Department of Medical Microbiology, School of Basic Medical Science, Suzhou Medical College, Soochow University, Suzhou, China; School of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaMOE Key Laboratory of Geriatric Diseases & Immunology, Suzhou Key Laboratory of Pathogen Bioscience & Anti-infective Medicine, Department of Medical Microbiology, School of Basic Medical Science, Suzhou Medical College, Soochow University, Suzhou, ChinaMOE Key Laboratory of Geriatric Diseases & Immunology, Suzhou Key Laboratory of Pathogen Bioscience & Anti-infective Medicine, Department of Medical Microbiology, School of Basic Medical Science, Suzhou Medical College, Soochow University, Suzhou, China; School of Public Health, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. Department of Emergency Medicine, Second Affiliated Hospital, Department of Epidemiology and Biostatistics, School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.Refractory infections caused by multidrug-resistant bacteria pose a significant threat to public health. Here we report that ibuprofen inhibits conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, blaNDM, blaKPC, tet(X4), and tmexCD1-toprJ1. Mechanistic studies suggest that ibuprofen reduces ATP production and inhibits conjugation-related genes. The inhibitory effect of ibuprofen on conjugation has significant clinical implications for preventing the spread of multidrug resistance, opening new therapeutic avenues to combat multidrug-resistant bacteria.http://www.sciencedirect.com/science/article/pii/S2213716525000153IbuprofenConjugative transferAntimicrobial resistanceType IV secretion systemATP level |
| spellingShingle | Guangfen Zhang Chunli Li Xiaofan Li Yuanyuan Li Yunbing Li Xiangkun Zeng Chen Xu Shuyan Wu Ning Dong Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes Journal of Global Antimicrobial Resistance Ibuprofen Conjugative transfer Antimicrobial resistance Type IV secretion system ATP level |
| title | Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes |
| title_full | Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes |
| title_fullStr | Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes |
| title_full_unstemmed | Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes |
| title_short | Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes |
| title_sort | ibuprofen prevents the conjugative transfer of plasmid mediated antimicrobial resistance genes |
| topic | Ibuprofen Conjugative transfer Antimicrobial resistance Type IV secretion system ATP level |
| url | http://www.sciencedirect.com/science/article/pii/S2213716525000153 |
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