Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes

Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes

Refractory infections caused by multidrug-resistant bacteria pose a significant threat to public health. Here we report that ibuprofen inhibits conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, blaNDM, blaKPC, tet(X4), and tmexCD1-...

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Bibliographic Details
Main Authors: Guangfen Zhang, Chunli Li, Xiaofan Li, Yuanyuan Li, Yunbing Li, Xiangkun Zeng, Chen Xu, Shuyan Wu, Ning Dong
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Ibuprofen
Conjugative transfer
Antimicrobial resistance
Type IV secretion system
ATP level
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716525000153
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