Clinical characteristics and comparative analysis of PD-1/PD-L1 inhibitor-induced pituitary dysfunction versus other pituitary disorders

Clinical characteristics and comparative analysis of PD-1/PD-L1 inhibitor-induced pituitary dysfunction versus other pituitary disorders

Abstract This study aims to investigate the clinical characteristics of programmed cell death protein-1 (PD-1) or programmed cell death ligand-1 (PD-L1) inhibitors-induced pituitary injury (pituitary-irAE) by comparing with other pituitary diseases. We retrospectively reviewed clinical records of pa...

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Bibliographic Details
Main Authors: Yan Xiao, Deyue Jiang, Shengjie Wang, Lei Fu, Lingtong Ye, Erhan Zheng, Zhaohui Lv, Yiming Mu, Wenwen Gong, Qinghua Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Pituitary dysfunction induced by immune checkpoint inhibitors
Programmed cell death-1 protein
Programmed cell death ligand-1
Idiopathic isolated ACTH deficiency
Lymphocytic hypophysitis
Online Access:https://doi.org/10.1038/s41598-025-05563-3
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https://doi.org/10.1038/s41598-025-05563-3

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