Involvement of Nuclear Receptors PPAR-α, PPAR-γ, and the Transcription Factor Nrf2 in Cellular Protection Against Oxidative Stress Regulated by H<sub>2</sub>S and Induced by Hypoxia–Reoxygenation and High Glucose in Primary Cardiomyocyte Cultures

Involvement of Nuclear Receptors PPAR-α, PPAR-γ, and the Transcription Factor Nrf2 in Cellular Protection Against Oxidative Stress Regulated by H<sub>2</sub>S and Induced by Hypoxia–Reoxygenation and High Glucose in Primary Cardiomyocyte Cultures

Myocardial oxidative stress increases under conditions of hyperglycemia and ischemia/reperfusion (I/R) injury, leading to cellular damage. Inhibition of oxidative stress is involved in the cardioprotective effects of hydrogen sulfide (H<sub>2</sub>S) during I/R and diabetes, and H<sub...

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Main Authors: Luz Ibarra-Lara, Araceli Sánchez-López, Leonardo del Valle-Mondragon, Elizabeth Soria-Castro, Gabriela Zarco-Olvera, Mariana Patlán, Verónica Guarner-Lans, Juan Carlos Torres-Narváez, Angélica Ruiz-Ramírez, Fernando Díaz de León-Sánchez, Víctor Hugo Oidor-Chan, Vicente Castrejón-Téllez
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antioxidants
Subjects:
sodium hydrosulfide (NaHS)
hypoxia–reoxygenation
hyperglycemia
PPAR-α
PPAR-γ
antioxidant capacity
Online Access:https://www.mdpi.com/2076-3921/14/4/482
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