Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers

Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers

Abstract Background SARS-CoV-2 and other viruses rely on the protease function of the TMPRSS2 protein to invade host cells. Despite cancer patients often experience poorer outcomes following SARS-CoV-2 infection, the role of TMPRSS2 in different cancer types has not yet been analyzed in detail. Ther...

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Main Authors: Karthikeyan Subbarayan, Helena Bieber, Chiara Massa, Felipe Adonis Escalona Rodríguez, SM Al Amin Hossain, Lisa Neuder, Wafa Wahbi, Tuula Salo, Sandy Tretbar, Ahmed Al-Samadi, Barbara Seliger
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
SARS-CoV-2
TMPRSS2
Immune escape
Immune response
Tumors
Online Access:https://doi.org/10.1186/s12967-025-06177-z
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https://doi.org/10.1186/s12967-025-06177-z

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