Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis

Abstract Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the consequences of PDGFR‐β activation, we developed a model of primary renal fibrosis using transgenic mice with PDGFR‐β activation speci...

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Main Authors: Eva M Buhl, Sonja Djudjaj, Barbara M Klinkhammer, Katja Ermert, Victor G Puelles, Maja T Lindenmeyer, Clemens D Cohen, Chaoyong He, Erawan Borkham‐Kamphorst, Ralf Weiskirchen, Bernd Denecke, Panuwat Trairatphisan, Julio Saez‐Rodriguez, Tobias B Huber, Lorin E Olson, Jürgen Floege, Peter Boor
Format: Article
Language:English
Published: Springer Nature 2020-01-01
Series:EMBO Molecular Medicine
Subjects:
anemia
chronic kidney disease
fibroblasts
PDGFR
progression
Online Access:https://doi.org/10.15252/emmm.201911021
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https://doi.org/10.15252/emmm.201911021

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