MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance

MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance

Abstract Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a ra...

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Main Authors: Ying Yu Liang, Khalidah Khalid, Hai Van Le, Hui Min Vivian Teo, Mindaugas Raitelaitis, Marc-Antoine Gerault, Jane Jia Hui Lee, Jiawen Lyu, Allison Chan, Anand Devaprasath Jeyasekharan, Wai Leong Tam, Pär Nordlund, Nayana Prabhu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59505-8
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https://doi.org/10.1038/s41467-025-59505-8

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