In vivo profiling of the PE/PPE proteins of Mycobacterium tuberculosis reveals diverse contributions to virulence

Mycobacterium tuberculosis (M.tb) uses a plethora of cell surface and secreted virulence factors to survive within the host. Among these are the PE/PPE proteins, a pair of secretory families that have expanded to 168 members in M.tb. Most of these proteins are poorly characterized due in part to the...

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Bibliographic Details
Main Authors: Benjamin Koleske, Jessica Shen, Manish Gupta, William R. Bishai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1634229/full
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