Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives

Abstract Glioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor prognosis and a dismal five-year survival rate. Despite significant knowledge gains in tumour biology, meaningful advances in patient survival remain elusive. The field of neuro-oncology faces many disease o...

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Bibliographic Details
Main Authors: Niclas Skarne, Rochelle C. J. D’Souza, Helen M. Palethorpe, Kylah A. Bradbrook, Guillermo A. Gomez, Bryan W. Day
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Acta Neuropathologica Communications
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Online Access:https://doi.org/10.1186/s40478-025-01928-x
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