Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier
Head and neck squamous cell carcinoma (HNSCC) remains a challenge due to limited prognostic biomarkers and therapeutic options. The tumor microenvironment (TME), particularly the desmoplastic reaction (DR) characterized by stromal fibrosis, plays a crucial role in cancer progression and resistance t...
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Main Authors: | Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto |
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Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2025-02-01
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Series: | Therapeutic Advances in Medical Oncology |
Online Access: | https://doi.org/10.1177/17588359251317144 |
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