Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein

Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein

Interfering hepatitis B virus (HBV) capsid assembly holds promise as a therapeutic approach for chronic hepatitis B (CHB). Novel anti-HBV agents are urgently needed to overcome drug resistance challenges, with targeted protein degradation (TPD) emerging as a hopeful strategy. Herein, we report the f...

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Bibliographic Details
Main Authors: Shujing Xu, Ya Wang, Dazhou Shi, Shuo Wang, Lijun Qiao, Ge Yang, Yang Zhou, Xinyong Liu, Shuo Wu, Yuhuan Li, Peng Zhan
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Hepatitis B virus
Core protein
Hydrophobic tagging
Degrader
Mechanism verification
Drug resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001108
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