Acinar cells modulate the tumor microenvironment through the promotion of M1 macrophage polarization via macrophage endocytosis in pancreatic cancer

Abstract Background Pancreatic ductal adenocarcinoma (PDA) is a highly aggressive and fatal cancer. M1 macrophages are generally considered to have anti-tumor properties, capable of suppressing tumor growth and metastasis by secreting pro-inflammatory cytokines and enhancing the immune response. Aim...

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Bibliographic Details
Main Authors: Congjia Ma, Wenbo Zhu, Xiulin Hu, Deli Wu, Xintong Zhao, Yiqi Du, Xiangyu Kong
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
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Online Access:https://doi.org/10.1007/s12672-025-02244-5
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