Asymmetric white matter degeneration in amyotrophic lateral sclerosis: a diffusion kurtosis imaging study of motor and extra-motor pathways

Asymmetric white matter degeneration in amyotrophic lateral sclerosis: a diffusion kurtosis imaging study of motor and extra-motor pathways

BackgroundAmyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that lacks effective early biomarkers. This study investigated the potential of diffusion kurtosis imaging (DKI) as a non-invasive biomarker for detecting and monitoring ALS progression through a comprehensive a...

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Bibliographic Details
Main Authors:	Juan Carlos Quizhpilema, Ane Legarda, José Manuel Hidalgo, Pablo Lecumberri, Ivonne Jerico, Teresa Cabada
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Neuroscience
Subjects:	amyotrophic lateral sclerosis diffusion kurtosis imaging white matter tractography biomarkers corticospinal tract
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1581719/full
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