In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene.

In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene.

Poor patient compliance, untoward reactions and unstable blood drug levels after the bolus administration are impeding the pharmacotherapy for insobriety. A long-acting preparation may address these limitations. The aim of this paper was to further investigate the in vitro characteristics and in viv...

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Bibliographic Details
Main Authors: Xiangyang Xie, Wen Lin, Chuanfeng Xing, Yanfang Yang, Qiang Chi, Hui Zhang, Ying Li, Zhiping Li, Yang Yang, Zhenbo Yang, Mingyuang Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125953
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