Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians
Abstract Background Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. Chlormethine gel is recommended by major treatment guidelines as a first-line option...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2024-11-01
|
| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-024-01305-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832572023695474688 |
|---|---|
| author | Larisa Geskin Christiane Querfeld Emmilia Hodak Neda Nikbakht Evangelia Papadavid Marco Ardigò Ulrike Wehkamp Martine Bagot |
| author_facet | Larisa Geskin Christiane Querfeld Emmilia Hodak Neda Nikbakht Evangelia Papadavid Marco Ardigò Ulrike Wehkamp Martine Bagot |
| author_sort | Larisa Geskin |
| collection | DOAJ |
| description | Abstract Background Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. Chlormethine gel is recommended by major treatment guidelines as a first-line option for stage IA–IIA disease, and, on the basis of these guidelines, used in combination with other therapies in patients with advanced-stage MF in clinical practice. Objectives To provide guidance regarding the use of chlormethine gel for patients with all stages of MF, based on clinical expertise. Methods Opinions on best practices regarding the use of chlormethine gel were collected through discussions that involved eight clinicians with extensive experience in treating patients with MF. Results Chlormethine gel can be used as monotherapy in first- or second-line treatment of early-stage MF. In first-line, chlormethine gel monotherapy is prescribed for stage IA MF, and is particularly convenient for patients unable/unwilling to travel for hospital-based phototherapy, patients with thick plaques or palmoplantar involvement, when ultraviolet treatment is contraindicated, and for sanctuary sites. Chlormethine gel is also an appropriate first-line monotherapy for patients with stage IB or IIA MF; it may be used as part of combination regimens in these patients as well. For patients with late-stage MF, skin-directed treatments such as chlormethine gel should be combined with systemic therapies. Conclusions Chlormethine gel is a safe and effective treatment option that can be used in all stages of MF, either as monotherapy or in combination, depending on disease stage and patient characteristics and needs. |
| format | Article |
| id | doaj-art-ab30fe38de4b4939a84e496f16dff308 |
| institution | Kabale University |
| issn | 2193-8210 2190-9172 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj-art-ab30fe38de4b4939a84e496f16dff3082025-02-02T12:09:48ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722024-11-01151617310.1007/s13555-024-01305-xChlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to CliniciansLarisa Geskin0Christiane Querfeld1Emmilia Hodak2Neda Nikbakht3Evangelia Papadavid4Marco Ardigò5Ulrike Wehkamp6Martine Bagot7Department of Dermatology, Columbia University Medical Center, Columbia UniversityDivision of Dermatology and Department of Pathology, City of Hope National Medical Center, Beckman Research InstituteDavidoff Cancer Center, Rabin Medical Center, Tel Aviv UniversityDepartment of Dermatology and Cutaneous Biology, Thomas Jefferson UniversityNational Center of Excellence for Rare Disease, 2nd Department of Dermatology and Venereology, Attikon University General HospitalDermatology Unit, IRCCS Humanitas Research HospitalMSH Medical School HamburgDepartment of Dermatology, AP-HP, Université Paris CitéHôpital Saint-LouisAbstract Background Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. Chlormethine gel is recommended by major treatment guidelines as a first-line option for stage IA–IIA disease, and, on the basis of these guidelines, used in combination with other therapies in patients with advanced-stage MF in clinical practice. Objectives To provide guidance regarding the use of chlormethine gel for patients with all stages of MF, based on clinical expertise. Methods Opinions on best practices regarding the use of chlormethine gel were collected through discussions that involved eight clinicians with extensive experience in treating patients with MF. Results Chlormethine gel can be used as monotherapy in first- or second-line treatment of early-stage MF. In first-line, chlormethine gel monotherapy is prescribed for stage IA MF, and is particularly convenient for patients unable/unwilling to travel for hospital-based phototherapy, patients with thick plaques or palmoplantar involvement, when ultraviolet treatment is contraindicated, and for sanctuary sites. Chlormethine gel is also an appropriate first-line monotherapy for patients with stage IB or IIA MF; it may be used as part of combination regimens in these patients as well. For patients with late-stage MF, skin-directed treatments such as chlormethine gel should be combined with systemic therapies. Conclusions Chlormethine gel is a safe and effective treatment option that can be used in all stages of MF, either as monotherapy or in combination, depending on disease stage and patient characteristics and needs.https://doi.org/10.1007/s13555-024-01305-xMycosis fungoidesChlormethine gelBest practicesGuidance |
| spellingShingle | Larisa Geskin Christiane Querfeld Emmilia Hodak Neda Nikbakht Evangelia Papadavid Marco Ardigò Ulrike Wehkamp Martine Bagot Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians Dermatology and Therapy Mycosis fungoides Chlormethine gel Best practices Guidance |
| title | Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians |
| title_full | Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians |
| title_fullStr | Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians |
| title_full_unstemmed | Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians |
| title_short | Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians |
| title_sort | chlormethine gel for treatment of patients with mycosis fungoides best practices and guidance to clinicians |
| topic | Mycosis fungoides Chlormethine gel Best practices Guidance |
| url | https://doi.org/10.1007/s13555-024-01305-x |
| work_keys_str_mv | AT larisageskin chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT christianequerfeld chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT emmiliahodak chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT nedanikbakht chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT evangeliapapadavid chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT marcoardigo chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT ulrikewehkamp chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians AT martinebagot chlormethinegelfortreatmentofpatientswithmycosisfungoidesbestpracticesandguidancetoclinicians |