AT2 Receptor-Interacting Proteins ATIPs in the Brain
A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The present paper focuses on AT2 receptors, which hav...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/513047 |
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| _version_ | 1832548074644307968 |
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| author | Sylvie Rodrigues-Ferreira Erwann le Rouzic Traci Pawlowski Anand Srivastava Florence Margottin-Goguet Clara Nahmias |
| author_facet | Sylvie Rodrigues-Ferreira Erwann le Rouzic Traci Pawlowski Anand Srivastava Florence Margottin-Goguet Clara Nahmias |
| author_sort | Sylvie Rodrigues-Ferreira |
| collection | DOAJ |
| description | A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The present paper focuses on AT2 receptors, which have been reported to have neuroprotective effects on stroke, degenerative diseases, and cognitive functions. Our group has identified a family of AT2 receptor interacting proteins (ATIPs) comprising three major members (ATIP1, ATIP3, and ATIP4) with different intracellular localization. Of interest, all ATIP members are expressed in brain tissues and carry a conserved domain able to interact with the AT2 receptor intracellular tail, suggesting a role in AT2-mediated brain functions. We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation. These studies point to a functional role of the AT2/ATIP1 axis in cognition. |
| format | Article |
| id | doaj-art-aafb699a08b44e30b4b8a4d0de9e108f |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-aafb699a08b44e30b4b8a4d0de9e108f2025-02-03T06:42:15ZengWileyInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/513047513047AT2 Receptor-Interacting Proteins ATIPs in the BrainSylvie Rodrigues-Ferreira0Erwann le Rouzic1Traci Pawlowski2Anand Srivastava3Florence Margottin-Goguet4Clara Nahmias5Inserm U1016, Paris 75014, FranceInserm U1016, Paris 75014, FranceJ.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, SC 29646, USAJ.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, SC 29646, USAInserm U1016, Paris 75014, FranceInserm U1016, Paris 75014, FranceA complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The present paper focuses on AT2 receptors, which have been reported to have neuroprotective effects on stroke, degenerative diseases, and cognitive functions. Our group has identified a family of AT2 receptor interacting proteins (ATIPs) comprising three major members (ATIP1, ATIP3, and ATIP4) with different intracellular localization. Of interest, all ATIP members are expressed in brain tissues and carry a conserved domain able to interact with the AT2 receptor intracellular tail, suggesting a role in AT2-mediated brain functions. We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation. These studies point to a functional role of the AT2/ATIP1 axis in cognition.http://dx.doi.org/10.1155/2013/513047 |
| spellingShingle | Sylvie Rodrigues-Ferreira Erwann le Rouzic Traci Pawlowski Anand Srivastava Florence Margottin-Goguet Clara Nahmias AT2 Receptor-Interacting Proteins ATIPs in the Brain International Journal of Hypertension |
| title | AT2 Receptor-Interacting Proteins ATIPs in the Brain |
| title_full | AT2 Receptor-Interacting Proteins ATIPs in the Brain |
| title_fullStr | AT2 Receptor-Interacting Proteins ATIPs in the Brain |
| title_full_unstemmed | AT2 Receptor-Interacting Proteins ATIPs in the Brain |
| title_short | AT2 Receptor-Interacting Proteins ATIPs in the Brain |
| title_sort | at2 receptor interacting proteins atips in the brain |
| url | http://dx.doi.org/10.1155/2013/513047 |
| work_keys_str_mv | AT sylvierodriguesferreira at2receptorinteractingproteinsatipsinthebrain AT erwannlerouzic at2receptorinteractingproteinsatipsinthebrain AT tracipawlowski at2receptorinteractingproteinsatipsinthebrain AT anandsrivastava at2receptorinteractingproteinsatipsinthebrain AT florencemargottingoguet at2receptorinteractingproteinsatipsinthebrain AT claranahmias at2receptorinteractingproteinsatipsinthebrain |