Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information
Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and ex...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
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| Series: | Clinical and Translational Medicine |
| Online Access: | https://doi.org/10.1002/ctm2.70130 |
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| _version_ | 1832582254560280576 |
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| author | Lingrong Kong Yingjun Yang Chao Yuan Xing Wei Xinyao Zhou Jia Zhou Ya Xing Gang Zou Qianqian Sun Luyao Cai Qiufeng Liang Yao Zhang Hongkun Wang Zesi Liu Di Wu Luming Sun |
| author_facet | Lingrong Kong Yingjun Yang Chao Yuan Xing Wei Xinyao Zhou Jia Zhou Ya Xing Gang Zou Qianqian Sun Luyao Cai Qiufeng Liang Yao Zhang Hongkun Wang Zesi Liu Di Wu Luming Sun |
| author_sort | Lingrong Kong |
| collection | DOAJ |
| description | Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost‐effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies. |
| format | Article |
| id | doaj-art-aad8c569a8a94ce889a1e2cf9dfd22fd |
| institution | Kabale University |
| issn | 2001-1326 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj-art-aad8c569a8a94ce889a1e2cf9dfd22fd2025-01-30T03:56:55ZengWileyClinical and Translational Medicine2001-13262024-12-011412n/an/a10.1002/ctm2.70130Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium informationLingrong Kong0Yingjun Yang1Chao Yuan2Xing Wei3Xinyao Zhou4Jia Zhou5Ya Xing6Gang Zou7Qianqian Sun8Luyao Cai9Qiufeng Liang10Yao Zhang11Hongkun Wang12Zesi Liu13Di Wu14Luming Sun15Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaResearch and Development DepartmentCelula (China) Medical Technology Co., Ltd.Chengdu ChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaResearch and Development DepartmentCelula (China) Medical Technology Co., Ltd.Chengdu ChinaDepartment of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChinaDear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost‐effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.https://doi.org/10.1002/ctm2.70130 |
| spellingShingle | Lingrong Kong Yingjun Yang Chao Yuan Xing Wei Xinyao Zhou Jia Zhou Ya Xing Gang Zou Qianqian Sun Luyao Cai Qiufeng Liang Yao Zhang Hongkun Wang Zesi Liu Di Wu Luming Sun Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information Clinical and Translational Medicine |
| title | Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information |
| title_full | Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information |
| title_fullStr | Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information |
| title_full_unstemmed | Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information |
| title_short | Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information |
| title_sort | noninvasive detection of twin zygosity using genome wide linkage disequilibrium information |
| url | https://doi.org/10.1002/ctm2.70130 |
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