Cost–effectiveness of cetuximab combined with radiotherapy versus radiotherapy alone in locally advanced head and neck cancer in Spain
Aim: To estimate the cost–effectiveness of cetuximab in combination with radiotherapy compared with radiotherapy alone, for the treatment of locally advanced head and neck cancer patients in Spain. Methods: A probabilistic Markov model (second-order Monte Carlo simulation) with a five-year time h...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Becaris Publishing Limited
2025-01-01
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| Series: | Journal of Comparative Effectiveness Research |
| Subjects: | |
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| Summary: | Aim: To estimate the cost–effectiveness of cetuximab in combination with radiotherapy compared with
radiotherapy alone, for the treatment of locally advanced head and neck cancer patients in Spain.
Methods: A probabilistic Markov model (second-order Monte Carlo simulation) with a five-year time
horizon and quarterly Markov cycles was performed from the perspective of the Spanish National Health
System (NHS). Results: The additional cost and quality-adjusted life-year (QALY) gain per patient receiving
radiotherapy in combination with cetuximab compared with radiotherapy alone was €4356 (95% CI:
€4350–4362) and 0.2380 (95% CI: 0.2370–0.2391) QALY, respectively. The incremental cost per QALY gain
was €18,303 (95% CI: €18,243–18,354) with a probability of cost–effectiveness of 65.4% for a willingness
to pay of €30,000 per QALY gained. Conclusion: According to the results of this analysis, the addition of
cetuximab to radiotherapy would be a cost-effective alternative to radiotherapy alone in the treatment
of locally advanced head and neck cancer in Spain. |
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| ISSN: | 2042-6313 |