An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing
Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in the microenvironment of wound infection to promote wound healing. In this study, a multifunctional hydrogel drug delivery system (HA@TA-Okra) was constructed through the integrat...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-025-03148-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571322523189248 |
|---|---|
| author | Ziyi Zhou Dengjun Zhang Xuchao Ning Linbo Jin Yijing Lin Chen Liang Xin Wen Tianhao Huang Junli Zhou Yiming Zhang |
| author_facet | Ziyi Zhou Dengjun Zhang Xuchao Ning Linbo Jin Yijing Lin Chen Liang Xin Wen Tianhao Huang Junli Zhou Yiming Zhang |
| author_sort | Ziyi Zhou |
| collection | DOAJ |
| description | Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in the microenvironment of wound infection to promote wound healing. In this study, a multifunctional hydrogel drug delivery system (HA@TA-Okra) was constructed through the integration of hyaluronic acid methacrylate (HAMA) matrix with tannic acid (TA) and okra extract. The composition and structural characteristics of HA@TA-Okra system and its unique advantages in the treatment of diverse wounds were systematically evaluated. TA, due to its unique chemical structure, is able to anchor within the HAMA network through interactions and cross-linking, conferring exceptional mechanical strength and stability to the hydrogel. Both TA and okra extract possess antioxidant and antibacterial properties, and when they two acts synergistically they can effectively scavenge free radicals, enhance antibacterial action, diminishing the risk of wound infection. In vitro experiments revealed that HA@TA-Okra system has superior properties, such as rapid gel response, remarkable swelling regulation, and potent antioxidant ability. Furthermore, the HA@TA-Okra system significantly outperformed conventional dressings in terms of hemostatic performance in a rat hemorrhage model. We further evaluated the repair role of HA@TA-Okra system in vivo by establishing an animal model of full-thickness skin defects and a model of infected total skin defects. The results confirmed its positive effects in fighting bacterial infection, reducing inflammation and promoting wound healing. In summary, the HA@TA-Okra system exhibits comprehensive properties such as antibacterial, antioxidant and hemostatic properties, which has a potential application in the field of tissue repair medicine. Graphical Abstract |
| format | Article |
| id | doaj-art-aab51d68e89145ca8ef6c5d4619c1128 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-aab51d68e89145ca8ef6c5d4619c11282025-02-02T12:41:05ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112210.1186/s12951-025-03148-wAn antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healingZiyi Zhou0Dengjun Zhang1Xuchao Ning2Linbo Jin3Yijing Lin4Chen Liang5Xin Wen6Tianhao Huang7Junli Zhou8Yiming Zhang9Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Plastic Surgery, Cheeloo College of Medicine, Qilu Hospital of Shandong University (Qingdao)Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityDepartment of Burn and Plastic surgery, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital)Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical UniversityAbstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in the microenvironment of wound infection to promote wound healing. In this study, a multifunctional hydrogel drug delivery system (HA@TA-Okra) was constructed through the integration of hyaluronic acid methacrylate (HAMA) matrix with tannic acid (TA) and okra extract. The composition and structural characteristics of HA@TA-Okra system and its unique advantages in the treatment of diverse wounds were systematically evaluated. TA, due to its unique chemical structure, is able to anchor within the HAMA network through interactions and cross-linking, conferring exceptional mechanical strength and stability to the hydrogel. Both TA and okra extract possess antioxidant and antibacterial properties, and when they two acts synergistically they can effectively scavenge free radicals, enhance antibacterial action, diminishing the risk of wound infection. In vitro experiments revealed that HA@TA-Okra system has superior properties, such as rapid gel response, remarkable swelling regulation, and potent antioxidant ability. Furthermore, the HA@TA-Okra system significantly outperformed conventional dressings in terms of hemostatic performance in a rat hemorrhage model. We further evaluated the repair role of HA@TA-Okra system in vivo by establishing an animal model of full-thickness skin defects and a model of infected total skin defects. The results confirmed its positive effects in fighting bacterial infection, reducing inflammation and promoting wound healing. In summary, the HA@TA-Okra system exhibits comprehensive properties such as antibacterial, antioxidant and hemostatic properties, which has a potential application in the field of tissue repair medicine. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03148-wHydrogelAntibacterialAntioxidantHemostasisInfected wound |
| spellingShingle | Ziyi Zhou Dengjun Zhang Xuchao Ning Linbo Jin Yijing Lin Chen Liang Xin Wen Tianhao Huang Junli Zhou Yiming Zhang An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing Journal of Nanobiotechnology Hydrogel Antibacterial Antioxidant Hemostasis Infected wound |
| title | An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing |
| title_full | An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing |
| title_fullStr | An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing |
| title_full_unstemmed | An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing |
| title_short | An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing |
| title_sort | antibacterial antioxidant and hemostatic hydrogel accelerates infectious wound healing |
| topic | Hydrogel Antibacterial Antioxidant Hemostasis Infected wound |
| url | https://doi.org/10.1186/s12951-025-03148-w |
| work_keys_str_mv | AT ziyizhou anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT dengjunzhang anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT xuchaoning anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT linbojin anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT yijinglin anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT chenliang anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT xinwen anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT tianhaohuang anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT junlizhou anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT yimingzhang anantibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT ziyizhou antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT dengjunzhang antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT xuchaoning antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT linbojin antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT yijinglin antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT chenliang antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT xinwen antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT tianhaohuang antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT junlizhou antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing AT yimingzhang antibacterialantioxidantandhemostatichydrogelacceleratesinfectiouswoundhealing |