Transcriptomic characterization of GMP-compliant regulatory macrophages (TRI-001) under inflammatory and hypoxic conditions: a comparative analysis across macrophage subtypes

Transcriptomic characterization of GMP-compliant regulatory macrophages (TRI-001) under inflammatory and hypoxic conditions: a comparative analysis across macrophage subtypes

Abstract Background Regulatory macrophages (Mreg) represent a unique subset of macrophages known for their angiogenic and anti-inflammatory properties, positioning them as promising candidates for cell-based therapies. Recently, we have differentiated and characterized a distinct Mreg subtype (TRI-0...

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Main Authors: Karina Zitta, Rouven Berndt, Katharina Hess, Fred Fändrich, Olga Gurvich, Katja Sirviö, Tuija Kekarainen, Lars Hummitzsch, Yuk Lung Wong, Ole Sattler, Steven Braem, Mark Krebs, Axel Fudickar, Sibille Engels, Nicole Flack, Markus Steinfath, Martin Albrecht
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-025-06548-6
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