Biological Functions and Clinical Significance of the ABCG1 Transporter
ATP-binding cassette (ABC) transporters are a large family of proteins that transport various substances across cell membranes using energy from ATP hydrolysis. ATP-binding cassette sub-family G member 1 (ABCG1) is a member of the ABCG subfamily of transporters and performs many important functions,...
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MDPI AG
2024-12-01
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| author | Stanislav Kotlyarov Anna Kotlyarova |
| author_facet | Stanislav Kotlyarov Anna Kotlyarova |
| author_sort | Stanislav Kotlyarov |
| collection | DOAJ |
| description | ATP-binding cassette (ABC) transporters are a large family of proteins that transport various substances across cell membranes using energy from ATP hydrolysis. ATP-binding cassette sub-family G member 1 (ABCG1) is a member of the ABCG subfamily of transporters and performs many important functions, such as the export of cholesterol and some other lipids across the membranes of various cells. Cholesterol transport is the mechanism that links metabolism and the innate immune system. Due to its lipid transport function, ABCG1 may contribute to the prevention of atherosclerosis and is involved in the functioning of the lung, pancreas, and other organs and systems. However, the full clinical significance of ABCG1 is still unknown and is a promising area for future research. |
| format | Article |
| id | doaj-art-aab16c5962d346928d9ae17ef6367fae |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-aab16c5962d346928d9ae17ef6367fae2025-01-24T13:23:17ZengMDPI AGBiology2079-77372024-12-01141810.3390/biology14010008Biological Functions and Clinical Significance of the ABCG1 TransporterStanislav Kotlyarov0Anna Kotlyarova1Department of Nursing, Ryazan State Medical University, 390026 Ryazan, RussiaDepartment of Pharmacy Management and Economics, Ryazan State Medical University, 390026 Ryazan, RussiaATP-binding cassette (ABC) transporters are a large family of proteins that transport various substances across cell membranes using energy from ATP hydrolysis. ATP-binding cassette sub-family G member 1 (ABCG1) is a member of the ABCG subfamily of transporters and performs many important functions, such as the export of cholesterol and some other lipids across the membranes of various cells. Cholesterol transport is the mechanism that links metabolism and the innate immune system. Due to its lipid transport function, ABCG1 may contribute to the prevention of atherosclerosis and is involved in the functioning of the lung, pancreas, and other organs and systems. However, the full clinical significance of ABCG1 is still unknown and is a promising area for future research.https://www.mdpi.com/2079-7737/14/1/8ABC transportersABCG1lipid metabolismtransportcholesterolatherosclerosis |
| spellingShingle | Stanislav Kotlyarov Anna Kotlyarova Biological Functions and Clinical Significance of the ABCG1 Transporter Biology ABC transporters ABCG1 lipid metabolism transport cholesterol atherosclerosis |
| title | Biological Functions and Clinical Significance of the ABCG1 Transporter |
| title_full | Biological Functions and Clinical Significance of the ABCG1 Transporter |
| title_fullStr | Biological Functions and Clinical Significance of the ABCG1 Transporter |
| title_full_unstemmed | Biological Functions and Clinical Significance of the ABCG1 Transporter |
| title_short | Biological Functions and Clinical Significance of the ABCG1 Transporter |
| title_sort | biological functions and clinical significance of the abcg1 transporter |
| topic | ABC transporters ABCG1 lipid metabolism transport cholesterol atherosclerosis |
| url | https://www.mdpi.com/2079-7737/14/1/8 |
| work_keys_str_mv | AT stanislavkotlyarov biologicalfunctionsandclinicalsignificanceoftheabcg1transporter AT annakotlyarova biologicalfunctionsandclinicalsignificanceoftheabcg1transporter |