Tetrahydrobiopterin as a rheostat of cell resistance to oxidant injury

Tetrahydrobiopterin (BH4) deficiency is caused by genetic abnormalities that impair its biosynthesis and recycling, which trigger neurochemical, metabolic, and redox imbalances. Low BH4 levels are also associated with hypoxia, reperfusion reoxygenation, endothelial dysfunction, and other conditions...

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Bibliographic Details
Main Authors: R. Steven Traeger, James Woodcock, Sidhartha Tan, Zhongjie Shi, Jeannette Vasquez-Vivar
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004257
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