CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

We present near-atomic-resolution cryoEM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium-bound states at 3.2 Å, 2.5 Å, 3.2 Å, and 2.9 Å. These structures, all obtained at nominally zero membrane potential in detergent micelles,...

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Bibliographic Details
Main Authors: Yangyu Wu, Yangyang Yan, Youshan Yang, Shumin Bian, Alberto Rivetta, Ken Allen, Fred J Sigworth
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
cryoEM
ion selectivity
dendrotoxin
inactivation
voltage sensor
biophysics
Online Access:https://elifesciences.org/articles/89459
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https://elifesciences.org/articles/89459

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