多功能纳米载体靶向传输 Survivin siRNA 抑制肝细胞癌增殖
【目的】研究RGD修饰、MRI可视的纳米载体（RGD-PEG-g-PEI-SPION）靶向传输SurvivinsiRNA至肝细胞癌抑制裸鼠肝癌生长的作用；探讨RGD-PEG-g-PEI-SPION对裸鼠肝癌的MRI显像功能。【方法】经皮下注射Bel-7402细胞构建裸鼠皮下荷瘤模型；经肿瘤生长抑制实验、肿瘤组织HE染色、免疫组织化学染色和肿瘤组织细胞凋亡试验评估RGD-PEG-g-PEI-SPION靶向传输SurvivinsiRNA对裸鼠肝癌的治疗功能；利用MRI成像分析RGD-PEG-g-PEI-SPION对肝细胞癌的靶向显像功能。【结果】裸鼠皮下荷瘤模型成功建立并经裸鼠尾静脉首次注射25d...
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2019-01-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Subjects: | |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43548490/ |
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