Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report
In recent years, with the opening of the era of precision therapy, the treatment of patients with positive driver genes is a hot issue in global research. EGFR is the most common driver gene in NSCLC, with a positivity rate of 17%. Although targeted drugs for EGFR mutations can benefit this populati...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-03-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_280_22 |
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| _version_ | 1832591253329412096 |
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| author | Sijia Zhang Leichong Chen Kuikui Zhu Rui Meng |
| author_facet | Sijia Zhang Leichong Chen Kuikui Zhu Rui Meng |
| author_sort | Sijia Zhang |
| collection | DOAJ |
| description | In recent years, with the opening of the era of precision therapy, the treatment of patients with positive driver genes is a hot issue in global research. EGFR is the most common driver gene in NSCLC, with a positivity rate of 17%. Although targeted drugs for EGFR mutations can benefit this population with efficacy, target therapy resistance inevitably occurs. The presented case suggests that a patient with advanced lung adenocarcinoma with EGFR mutation who developed pathological-type conversion of small cell lung cancer complicated with the development of hypertropic pulmonary osteoarthropathy (HPOA) after 6 months of targeted therapy. This case demonstrates that early diagnosis of HPOA can predict the occurrence of target resistance and pathologic conversion in patients with positive driver genes, providing new clues for the clinical management of lung cancer. |
| format | Article |
| id | doaj-art-aa67f7e933e14cabbdb77c10de24e216 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-aa67f7e933e14cabbdb77c10de24e2162025-01-22T15:15:22ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-03-0167121722210.4103/ijpm.ijpm_280_22Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case reportSijia ZhangLeichong ChenKuikui ZhuRui MengIn recent years, with the opening of the era of precision therapy, the treatment of patients with positive driver genes is a hot issue in global research. EGFR is the most common driver gene in NSCLC, with a positivity rate of 17%. Although targeted drugs for EGFR mutations can benefit this population with efficacy, target therapy resistance inevitably occurs. The presented case suggests that a patient with advanced lung adenocarcinoma with EGFR mutation who developed pathological-type conversion of small cell lung cancer complicated with the development of hypertropic pulmonary osteoarthropathy (HPOA) after 6 months of targeted therapy. This case demonstrates that early diagnosis of HPOA can predict the occurrence of target resistance and pathologic conversion in patients with positive driver genes, providing new clues for the clinical management of lung cancer.https://journals.lww.com/10.4103/ijpm.ijpm_280_22case reportegfr mutationhypertrophic pulmonary osteoarthropathy (hpoa)small cell conversiontargeted therapy resistance |
| spellingShingle | Sijia Zhang Leichong Chen Kuikui Zhu Rui Meng Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report Indian Journal of Pathology and Microbiology case report egfr mutation hypertrophic pulmonary osteoarthropathy (hpoa) small cell conversion targeted therapy resistance |
| title | Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report |
| title_full | Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report |
| title_fullStr | Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report |
| title_full_unstemmed | Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report |
| title_short | Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report |
| title_sort | small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced egfr mutated lung adenocarcinoma a case report |
| topic | case report egfr mutation hypertrophic pulmonary osteoarthropathy (hpoa) small cell conversion targeted therapy resistance |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_280_22 |
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