Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools

Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools

Abstract About 50% of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53R175H (p53R172H in mice) is a hotspot mutation in various cancer types. Therefore, monoclonal antibodies selectively targeting clinically relevant mutations like p53R175...

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Bibliographic Details
Main Authors: Diana Spiegelberg, Le-Ann Hwang, Khian Hong Pua, Sashwini Chandra Kumar, Xin Yu Koh, Xiao Hui Koh, Ram Kumar Selvaraju, Kanaga Sabapathy, Marika Nestor, David Lane
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Cancer diagnostics
Mutant p53
Intracellular targets
Molecular imaging
Online Access:https://doi.org/10.1038/s41598-024-83871-w
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https://doi.org/10.1038/s41598-024-83871-w

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