Menin inhibitor MI-503 exhibits potent anti-cancer activity in osteosarcoma

Abstract Small molecule Menin inhibitor recently has emerged as a new therapeutic by targeting the interaction of histone methyltransferase MLL1 (KMT2A) with Menin. MLL1 is associated with aggressive osteosarcoma (OS) in young adults. The purpose of the study is to explore whether Menin inhibitors h...

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Bibliographic Details
Main Authors: Shen Tian, Zhuang-Yu Hao, Deng-Hui Xu, Xuan-Zong Wang, Cheng-Cheng Shi, Yi Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-91351-y
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