Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts

Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts

Global knockout (KO) of the <i>Lrrk1</i> gene in mice causes severe osteopetrosis because of the failure of osteoclasts to resorb bone. The molecular mechanism of LRRK1 regulation of osteoclast function is not fully understood. Here, we performed a 2D DIGE phosphor-proteomics analysis to...

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Bibliographic Details
Main Authors: Weirong Xing, Yian Chen, Anakha Udayakumar, Haibo Zhao, Subburaman Mohan
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biology
Subjects:
<i>Lrrk1</i>
knockout mice
osteopetrosis
proteomics
phosphoprotein
cofilin 1
Online Access:https://www.mdpi.com/2079-7737/14/4/326
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https://www.mdpi.com/2079-7737/14/4/326

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