Mesenchymal stem cell-derived small extracellular vesicles reduced hepatic lipid accumulation in MASLD by suppressing mitochondrial fission

Mesenchymal stem cell-derived small extracellular vesicles reduced hepatic lipid accumulation in MASLD by suppressing mitochondrial fission

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease characterized by lipid accumulation in liver cells. Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) have great potential in repairing and regenera...

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Bibliographic Details
Main Authors: Yifei Chen, Fuji Yang, Yanjin Wang, Yujie Shi, Likang Liu, Wei Luo, Jing Zhou, Yongmin Yan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
MASLD
MSC
Small extracellular vesicles
DRP1
Mitochondrial fission
Online Access:https://doi.org/10.1186/s13287-025-04228-2
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https://doi.org/10.1186/s13287-025-04228-2

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