Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis
Ensuring a safe and secure supply of nutritious food for the ever growing global population necessitates the development of new eco-friendly fungicides to increase global food output by minimizing plant disease losses. Because of their broad biological relevance, imines are a promising target for fu...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2024.2448897 |
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| author | Joydeep Karan Aditi Kundu Robin Gogoi Kanchikeri Math Manjaiah Ashutosh Kumar Singh Koyel Mondal Rajesh Kumar Parshant Kaushik Priya Saini Virendra Singh Rana Najam Akhtar Shakil |
| author_facet | Joydeep Karan Aditi Kundu Robin Gogoi Kanchikeri Math Manjaiah Ashutosh Kumar Singh Koyel Mondal Rajesh Kumar Parshant Kaushik Priya Saini Virendra Singh Rana Najam Akhtar Shakil |
| author_sort | Joydeep Karan |
| collection | DOAJ |
| description | Ensuring a safe and secure supply of nutritious food for the ever growing global population necessitates the development of new eco-friendly fungicides to increase global food output by minimizing plant disease losses. Because of their broad biological relevance, imines are a promising target for fungicide development. To optimize the structure of imine derivatives for improved antifungal activity, twenty-seven Schiff bases derived from halogen-substituted benzenamines were prepared and characterized using spectral analysis in the present study. These compounds were investigated further for their in-vitro antifungal bio-efficacy against Rhizoctonia solani and Macrophomina phaseolina. Most of the compounds were effective against the test fungi with EC50 values ranging from 0.99 to 190.51 μg/mL. The substitution of chlorine at the phenyl ring attached to the carbon of the imine group resulted in the highest antifungal activity against both test fungi. The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme. |
| format | Article |
| id | doaj-art-aa103a03f33e4109a8eb2846949f84e8 |
| institution | Kabale University |
| issn | 1658-3655 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj-art-aa103a03f33e4109a8eb2846949f84e82025-01-28T13:58:39ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552025-12-0119110.1080/16583655.2024.2448897Synthesis of antifungal imines as inhibitors of ergosterol biosynthesisJoydeep Karan0Aditi Kundu1Robin Gogoi2Kanchikeri Math Manjaiah3Ashutosh Kumar Singh4Koyel Mondal5Rajesh Kumar6Parshant Kaushik7Priya Saini8Virendra Singh Rana9Najam Akhtar Shakil10Division of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Plant Pathology, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Soil Science and Agricultural Chemistry, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Agricultural Chemicals, ICAR-Indian Agricultural Research Institute, New Delhi, IndiaEnsuring a safe and secure supply of nutritious food for the ever growing global population necessitates the development of new eco-friendly fungicides to increase global food output by minimizing plant disease losses. Because of their broad biological relevance, imines are a promising target for fungicide development. To optimize the structure of imine derivatives for improved antifungal activity, twenty-seven Schiff bases derived from halogen-substituted benzenamines were prepared and characterized using spectral analysis in the present study. These compounds were investigated further for their in-vitro antifungal bio-efficacy against Rhizoctonia solani and Macrophomina phaseolina. Most of the compounds were effective against the test fungi with EC50 values ranging from 0.99 to 190.51 μg/mL. The substitution of chlorine at the phenyl ring attached to the carbon of the imine group resulted in the highest antifungal activity against both test fungi. The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.https://www.tandfonline.com/doi/10.1080/16583655.2024.2448897IminesRhizoctonia solaniMacrophomina phaseolinafungicideEC50 |
| spellingShingle | Joydeep Karan Aditi Kundu Robin Gogoi Kanchikeri Math Manjaiah Ashutosh Kumar Singh Koyel Mondal Rajesh Kumar Parshant Kaushik Priya Saini Virendra Singh Rana Najam Akhtar Shakil Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis Journal of Taibah University for Science Imines Rhizoctonia solani Macrophomina phaseolina fungicide EC50 |
| title | Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis |
| title_full | Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis |
| title_fullStr | Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis |
| title_full_unstemmed | Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis |
| title_short | Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis |
| title_sort | synthesis of antifungal imines as inhibitors of ergosterol biosynthesis |
| topic | Imines Rhizoctonia solani Macrophomina phaseolina fungicide EC50 |
| url | https://www.tandfonline.com/doi/10.1080/16583655.2024.2448897 |
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