IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers
Objectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers. Design and Methods. We treated 48 consecuti...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/567834 |
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| author | Figen Aydin Ahmet Kaya Levent Karapinar Mert Kumbaraci Ahmet Imerci Hasan Karapinar Cengiz Karakuzu Mustafa Incesu |
| author_facet | Figen Aydin Ahmet Kaya Levent Karapinar Mert Kumbaraci Ahmet Imerci Hasan Karapinar Cengiz Karakuzu Mustafa Incesu |
| author_sort | Figen Aydin |
| collection | DOAJ |
| description | Objectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers. Design and Methods. We treated 48 consecutive patients with diabetic foot ulcers with HBOT. Alterations of IGF-1 levels in patients whose wound healed with HBOT were compared with those in patients who did not benefit from HBOT. Results. There was no significant difference in initial IGF-1 levels between the two groups (P=0.399). The mean IGF-1 level increased with HBOT (P<0.05). In the healed group, the mean IGF-1 increase and the final values were significantly higher (P<0.05). In the nonhealed group, the mean IGF-1 increase was minus and the final values were not significantly different (P<0.05). The increase in IGF-1 level with HBOT was significantly higher in the healed group (P<0.001). Conclusions. IGF-1 increased significantly in the healed group. We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1. This alteration seems to be a predictive factor for wound healing in diabetic foot ulcers treated with HBOT. |
| format | Article |
| id | doaj-art-aa0a10d0e57f4ace837628ad60feb81b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-aa0a10d0e57f4ace837628ad60feb81b2025-02-03T00:59:40ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/567834567834IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot UlcersFigen Aydin0Ahmet Kaya1Levent Karapinar2Mert Kumbaraci3Ahmet Imerci4Hasan Karapinar5Cengiz Karakuzu6Mustafa Incesu7Neoks Hyperbaric Oxygen Therapy Center, Bornova, 35560 Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Tepecik Education and Research Hospital, Yenisehir, 35100 Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Tepecik Education and Research Hospital, Yenisehir, 35100 Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Tepecik Education and Research Hospital, Yenisehir, 35100 Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Tepecik Education and Research Hospital, Yenisehir, 35100 Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Tepecik Education and Research Hospital, Yenisehir, 35100 Izmir, TurkeyNeoks Hyperbaric Oxygen Therapy Center, Bornova, 35560 Izmir, TurkeyDepartment of Orthopaedics and Traumatology, Tepecik Education and Research Hospital, Yenisehir, 35100 Izmir, TurkeyObjectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers. Design and Methods. We treated 48 consecutive patients with diabetic foot ulcers with HBOT. Alterations of IGF-1 levels in patients whose wound healed with HBOT were compared with those in patients who did not benefit from HBOT. Results. There was no significant difference in initial IGF-1 levels between the two groups (P=0.399). The mean IGF-1 level increased with HBOT (P<0.05). In the healed group, the mean IGF-1 increase and the final values were significantly higher (P<0.05). In the nonhealed group, the mean IGF-1 increase was minus and the final values were not significantly different (P<0.05). The increase in IGF-1 level with HBOT was significantly higher in the healed group (P<0.001). Conclusions. IGF-1 increased significantly in the healed group. We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1. This alteration seems to be a predictive factor for wound healing in diabetic foot ulcers treated with HBOT.http://dx.doi.org/10.1155/2013/567834 |
| spellingShingle | Figen Aydin Ahmet Kaya Levent Karapinar Mert Kumbaraci Ahmet Imerci Hasan Karapinar Cengiz Karakuzu Mustafa Incesu IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers Journal of Diabetes Research |
| title | IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers |
| title_full | IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers |
| title_fullStr | IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers |
| title_full_unstemmed | IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers |
| title_short | IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers |
| title_sort | igf 1 increases with hyperbaric oxygen therapy and promotes wound healing in diabetic foot ulcers |
| url | http://dx.doi.org/10.1155/2013/567834 |
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