Advanced tissue technologies of blood-brain barrier organoids as high throughput toxicity readouts in drug development

Recent advancements in engineering Complex in vitro models (CIVMs) such as Blood-brain barrier (BBB) organoids offer promising platforms for preclinical drug testing. However, their application in drug development, and especially for the regulatory purposes of toxicity assessment, requires robust an...

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Bibliographic Details
Main Authors: Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar-Regenscheit
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024168442
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