Trigonella foenum-graecum L. protects against renal function decline in a mouse model of type 2 diabetic nephropathy by modulating the PI3K-Akt-ERK signaling pathway

Trigonella foenum-graecum L. protects against renal function decline in a mouse model of type 2 diabetic nephropathy by modulating the PI3K-Akt-ERK signaling pathway

ObjectivesTrigonella foenum-graecum L. (HLB) exhibits promising pharmacological properties for the treatment of type 2 diabetic nephropathy (DN). This study aims to enhance the understanding of HLB’s pharmacodynamic effects and elucidate the mechanisms underlying its therapeutic potential in DN.Meth...

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Main Authors: Yang Niu, Hongjuan Niu, Luxuan Chi, Peihang Li, Jiyang Du, Xiaoqian Wang, Xu He, Binan Lu, Zongran Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
Trigonella foenum-graecum L.
network pharmacology
PI3K-Akt-ERK pathway
untargeted metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1566723/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1566723/full

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