Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

In Salmonella enterica, aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme. When purH is eliminated in an otherwise wild-type strain, AICAR accumulates and indirectly inhibits synthesis of the...

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Bibliographic Details
Main Authors: Jannell V. Bazurto, Stephen P. Dearth, Eric D. Tague, Shawn R. Campagna, Diana M. Downs
Format: Article
Language:English
Published: Shared Science Publishers OG 2017-11-01
Series:Microbial Cell
Subjects:
aminoimidazole carboxamide ribotide (AICAR)
cyclic AMP (cAMP)
adenylate cyclase (CyaA)
cyclic AMP phosphodiesterase (Icc)
purine-histidine-thiamine (PHT)
metabolic network
thiamine biosynthesis
untargeted metabolomics
Online Access:http://microbialcell.com/researcharticles/untargeted-metabolomics-confirms-and-extends-the-understanding-of-the-impact-of-aminoimidazole-carboxamide-ribotide-aicar-in-the-metabolic-network-of-salmonella-enterica/
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http://microbialcell.com/researcharticles/untargeted-metabolomics-confirms-and-extends-the-understanding-of-the-impact-of-aminoimidazole-carboxamide-ribotide-aicar-in-the-metabolic-network-of-salmonella-enterica/

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