Preclinical safety and efficacy evaluation of the intrathecal transplantation of GMP-grade human umbilical cord mesenchymal stem cells for ischemic stroke

Preclinical safety and efficacy evaluation of the intrathecal transplantation of GMP-grade human umbilical cord mesenchymal stem cells for ischemic stroke

Intrathecal administration of human umbilical cord mesenchymal stem cells may be a promising approach for the treatment of stroke, but its safety, effectiveness, and mechanism remain to be elucidated. In this study, good manufacturing practice–grade human umbilical cord mesenchymal stem cells (5 × 1...

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Bibliographic Details
Main Authors: Zejia Huang, Jiaohua Jiang, Qingxia Peng, Mengzhi Jin, Yakun Dong, Xuejia Li, Ermei Luo, Haijia Chen, Yidong Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-03-01
Series:Neural Regeneration Research
Subjects:
angiogenesis
brain-derived neurotrophic factor
efficacy
human umbilical cord mesenchymal stem cells
intrathecal transplantation
ischemic stroke
neural cell
neurogenesis
safety
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00683
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