Hyperhomocysteinaemia in Behçet's Disease
Objectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD). Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fif...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2010/361387 |
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| _version_ | 1832564004584685568 |
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| author | Amira Hamzaoui Olfa Harzallah Rim Klii Silvia Mahjoub |
| author_facet | Amira Hamzaoui Olfa Harzallah Rim Klii Silvia Mahjoub |
| author_sort | Amira Hamzaoui |
| collection | DOAJ |
| description | Objectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD).
Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fifty healthy volunteers matched for age and sex with the BD group were included as a negative control group. Patients, with any condition that might affect plasma homocysteine concentration, were excluded.
Results. Mean serum homocysteine concentration was significantly higher in patients with BD than in the healthy controls (𝑃<.001), in patients with active disease (𝑃=.04), and in masculine gender (𝑃=.05).
There was no significant difference between homocysteine level and clinical involvement. Conclusions. We demonstrated that plasma total homocysteine level (tHcy) is increased in BD and correlated with disease activity. No association was found between homocysteine levels and clinical involvement. |
| format | Article |
| id | doaj-art-a96aa20048cc4efbae9044531e83ba0c |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-a96aa20048cc4efbae9044531e83ba0c2025-02-03T01:12:04ZengWileyBiochemistry Research International2090-22472090-22552010-01-01201010.1155/2010/361387361387Hyperhomocysteinaemia in Behçet's DiseaseAmira Hamzaoui0Olfa Harzallah1Rim Klii2Silvia Mahjoub3Department of Internal Medicine, Fattouma Bourguiba University Hospital, 5000 Monastir, TunisiaDepartment of Internal Medicine, Fattouma Bourguiba University Hospital, 5000 Monastir, TunisiaDepartment of Internal Medicine, Fattouma Bourguiba University Hospital, 5000 Monastir, TunisiaDepartment of Internal Medicine, Fattouma Bourguiba University Hospital, 5000 Monastir, TunisiaObjectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD). Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fifty healthy volunteers matched for age and sex with the BD group were included as a negative control group. Patients, with any condition that might affect plasma homocysteine concentration, were excluded. Results. Mean serum homocysteine concentration was significantly higher in patients with BD than in the healthy controls (𝑃<.001), in patients with active disease (𝑃=.04), and in masculine gender (𝑃=.05). There was no significant difference between homocysteine level and clinical involvement. Conclusions. We demonstrated that plasma total homocysteine level (tHcy) is increased in BD and correlated with disease activity. No association was found between homocysteine levels and clinical involvement.http://dx.doi.org/10.1155/2010/361387 |
| spellingShingle | Amira Hamzaoui Olfa Harzallah Rim Klii Silvia Mahjoub Hyperhomocysteinaemia in Behçet's Disease Biochemistry Research International |
| title | Hyperhomocysteinaemia in Behçet's Disease |
| title_full | Hyperhomocysteinaemia in Behçet's Disease |
| title_fullStr | Hyperhomocysteinaemia in Behçet's Disease |
| title_full_unstemmed | Hyperhomocysteinaemia in Behçet's Disease |
| title_short | Hyperhomocysteinaemia in Behçet's Disease |
| title_sort | hyperhomocysteinaemia in behcet s disease |
| url | http://dx.doi.org/10.1155/2010/361387 |
| work_keys_str_mv | AT amirahamzaoui hyperhomocysteinaemiainbehcetsdisease AT olfaharzallah hyperhomocysteinaemiainbehcetsdisease AT rimklii hyperhomocysteinaemiainbehcetsdisease AT silviamahjoub hyperhomocysteinaemiainbehcetsdisease |